Calciphylaxis is a poorly understood and highly morbid syndrome of vascular calcification and skin necrosis, first reported it in 1898

Calciphylaxis is a poorly understood and highly morbid syndrome of vascular calcification and skin necrosis, first reported it in 1898. The term ‘calciphylaxis’ was introduced in 1962 to characterize the syndrome of vascular calcification with cutaneous. The clinical importance of this syndrome was not recognized until a 1976 report by Gipstein et al, but since then, a multitude of case reports of calciphylaxis have documented data outlining its morbidity and therapeutic dilemmas, as well as attempting to gain a better understanding of its aetiology and pathogenesis.